Adjuvant used in DPT vaccine?
There are two types of DPT vaccine – plain and adsorbed.
Adsorption is usually carried out on a mineral carrier like aluminum phosphate Q or hydroxide. Adsorption increases the immunological effectiveness of the vaccine.
DIPHTHERIA TOXOID is prepared by formaldehyde treatment of toxin Q, standardized for potency, and adsorbed to aluminum salts Q, which enhance immunogenicity.
- Two preparations of diphtheria toxoids are formulated according to the limit of flocculation Q (Lf) content, a measure of the quantity of toxoid.
- The pediatric preparation (i.e., DTaP, DT, DTP) contains 6.7–25.0 Lf units of diphtheria toxoid per 0.5-mL dose; the adult preparation (i.e., dT) contains no more than 2 Lf units of toxoid per 0.5-mL dose.
- The higher-potency (i.e., D) formulation of toxoid is used for primary series and booster doses for children through 6 yr of age because of superior immunogenicity and minimal reactogenicity.
- For individuals 7 yr of age or older, dT is recommended for the primary series and booster doses because the lower concentration of diphtheria toxoid is adequately immunogenic and because increasing the content of diphtheria toxoid heightens reactogenicity with increasing age.