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Pharmacology

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CNS Part- 2

Question
13 out of 42
 

After few weeks on a drug, a patient reports profound thirst and the production of copious volumes of clear (dilute) urine each day. This is a fairly common, and unique, side effect of which of the following?



A Diazepam

B Fluoxetine

C Haloperidol

D Lithium

Ans. D Lithium
  1. Lithium treatment frequently causes polyuria and (as a consequence of extreme renal fluid loss) and polydipsia.
  2. The collecting ducts of the kidney lose the capacity to conserve water via antidiuretic hormone.
  3. This results in significantly increased free-water clearance, which is referred to as nephrogenic diabetes insipidus.
  4. Importantly, fluoxetine can cause the opposite and is known as SIADH.

CNS Part- 2 Flashcard List

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