All are hypercoagulable states, except: (AIIMS May 10)
|A||Protein C resistance|
|B||Factor V Leiden deficiency|
Factor V Leiden deficiency
Factor V Leiden deficiency….. Clot factor deficiency will cause bleeding so its not a hypercoagulable condition
Extra Edge: Factor V Leiden
1. Factor V Leiden thrombophilia is a genetically inherited disorder of blood clotting.
2. Factor V Leiden is a variant (mutated form) of human factor V that causes an increase in blood clotting (hypercoagulability).
3. In this disorder, the Leiden variant (form) of factor V cannot be inactivated by activated protein C, and so clotting is encouraged.
4. Factor V Leiden is the most common hereditary hypercoagulability.