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Pathology

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Cell Injury

Question
5 out of 32
 

All are reversible pathological changes except: (LQ)



A Hydropic swelling
B Fatty change

C Visible vacuoles in cytoplasm
D Karyorrhexis

Ans. D Karyorrhexis

a. Reversible cell injury-Ischemia decreases the oxidative phosphorylation in mitochondria causing reduction in ATP which ultimately results in.

i. Cellular swelling

ii. Loss of microvilli

iii. Bleb formation

iv. ER swelling

v. Myelin figures

vi. Dispersion of ribosomes

vii. Clumping of nuclear chromatin

vii. Small density lipid deposits

All these disturbances are reversible, if oxygen is restored.

b. Irreversible cell injury-Associated morphologically with severe swelling of mitochondria, extensive damage to plasma membranes and swelling of lysosomes which ruptures and autolysis begins. Large densities appear with lysis In ER and nuclear changes consists of pyknosis or karyolysis Or karyorrhexis

c. Consistent characteristics of irreversibility is mitochondrial dysfunction causing ATP depletion but membrane damage is a central factor in pathogenesis of irreversibility and calcium is an important mediator of the biochemical and morphological alterations leading to cell death.

Cell Injury Flashcard List

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