Gram Positive Bacilli
All are true about Corynebacterium diphtheriae except:
|A||Gravis has high fatality rate|
|B||Obstructive lesions in air passages are more common in laryngeal infection|
|C||Strain used for toxin production is Park Williams 8|
|D||Toxin is a lipopolysaccharide containing three fragments|
a. Diphtheria toxin is an protein having two components A and B having a molecular weight of 24,000 and 38,000 Da respectively.
b. When released by the bacterium it is inactive. Proteases in the infected tissues activate it.
c. In comparison to other biotypes, gravis produces more severe disease and high mortality.
d. As obstruction is common in laryngeal diphtheria, tracheostomy is mandatory if laryngeal diphtheria is diagnosed.