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Pathology

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Neoplasia

Question
24 out of 24
 

All are true about Follicular Lymphoma except:(LQ)



A t(14;18) translocation

B juxtaposition of IgH causes overexpression of BCL2 on chromosome 18

C increase in BCL2/BCL-XL buffer protecting lymphocytes from apoptosis leads to increase B-lymphocytes

D BCL2 overexpressing lymphocytes arise from explosive cell proliferation rather than reduced cell death.

Ans. D BCL2 overexpressing lymphocytes arise from explosive cell proliferation rather than reduced cell death

BCL2 overexpressing lymphocytes arise from reduced cell death rather than explosive cell proliferation, thus are indolent (slow growing) compared to other lymphomas

Neoplasia Flashcard List

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