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Pathology

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Neoplasia

Question
5 out of 6
 

All are true regarding breast cancer metastasis:(AIPG 2011)



A Epithelial-mesenchymal transcription (EMT) is the key feature in breast cancer

B EMT is promoted by loss of E-cadherin

C SNAIL and TWIST are transcriptional repressors that down-regulate E-cadherin

D Mir 10b inhibits metastasis

Ans. D Mir 10b inhibits metastasis

In EMT; carcinoma cells down-regulate epithelial markers (E-cadherin). miR 335 and miR 126 suppress metastasis while miR10b promotes metastasis.