All of the following are adverse effects of thalidomide except (AI 2012)
· Thalidomide was banned because of teratogenic effects (phocomelia). Now it has come again in the market for use as an anticancer drug in multiple myeloma and melanoma.
· Lenalidomide is its more potent and non-teratogenic derivative.
· Thalidomide most commonly causes sedation and constipation in cancer patients. It can also cause peripheral sensory neuropathy.
· Two enantiomers of thalidomide (R and S) are present but these are interconvertible in body, therefore racemic mixture is used.