All of the following are true about Asthma, Except: (PGI May 2011)
|A||Charcot Leyden crystals may be seen in sputum|
|B||Reversible Airflow obstruction is a characteristic feature|
|C||Large airways are involved|
|D||Small airways are not involved|
|E||Intermittent Asthma responds better to bronchodilator therapy than persistent Asthma|
Small airways are not involved
It is characterized by recurrent episodes of dyspnea Q, dry coughQ, and wheeze Q caused by reversible airwaysQ obstruction.
(Reversible airway obstruction is the most important criteria & is the most characteristic feature)
Three factors contribute to airway narrowing: (In both large & small airways)
1). Bronchial muscle contraction Q: Triggered by a variety of stimuli;
2). Mucosal swelling Q
3). Mucosal inflammation Q, caused by mast cell and basophil degranulation resulting in the release of inflammatory mediators; increased mucus production.