Loading....
Coupon Accepted Successfully!

Medicine

Open Flashcards

Endocrine

Question
12 out of 20
 

All of the following are true about amiodarone induced thyroid dysfunction except? (DNB June 2010)



A Both hyperthyroidism & Hypothyroidism can occur

B Hypothyroidism is more common in men

C Amiodarone inhibits deiodinase activity

D Amiodarone therapy is associated with initial reduction of serum T4 levels

Ans. B

Hypothyroidism is more common in men

Drug – induced hypothyroidism

1). Lithium carbonate

2). Amiodarone

a. Due to the high iodine content of the Amiodarone (37.3% by weight), abnormalities in thyroid function are common.

b. Amiodarone is structurally similar to thyroxine , which contributes to the effects of amiodarone on thyroid function.

c. Both under- and overactivity of the thyroid may occur on amiodarone treatment.

d. Hypothyroidism (slowing of the thyroid, due to the Wolff-Chaikoff effect) can also occur.

e. Hyperthyroidism (an overactive thyroid, due to the Jod-Basedow Effect) can also occur.

f. Amiodarone associated hypothyroidism is more common in women and individual with positive TPO antibodies.

g. Mechanism of Action: Amiodarone inhibits deiodinase activity.

h. Amiodarone therapy is associated with initial reduction of serum T4 levels

Endocrine Flashcard List

20 flashcards
1)
2)
3)
4)
5)
6)
7)
8)
9)
10)
11)
12)
13)
14)
15)
16)
17)
18)
19)
20)