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Pharmacology

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Analgesics

Question
13 out of 33
 

All of the following are true about opioids except?



A Naloxone is short acting

B Naltrexone used to lower craving in alcoholics

C Nalmefene can also be used in alcohol dependence

D Naloxone is more potent than naltrexone

Ans. D Naloxone is more potent than naltrexone (BG Katzung’ 10th Edition, 2010).

a. Naltrexone is more potent than naloxone. The drug has several uses: it is used in opioid detoxification, reducing alcohol craving and is also used as an anti-impotence drug.

b. Since endogenous opioids play an important role in producing impotence; naltrexone has been given an FDA approval.

c. It has been shown that if naltrexone is given orally per day in dose of 50mg; then the drug reduces craving in alcoholic patients apparently by reducing the pleasurable effects of alcohol (CMDT’2010, pp-980).

d. Acamprosate (dose 333-666 mg) 3 times a day given orally also been shown to reduce craving, and to maintain abstinence, and can be continued even during period of relapse.

e. Disulfiram is an alcohol dehydrogenase inhibitor and is an aversive agent. The drug is given in dose of 250-500 mg per day orally to prevent patients from taking alcohol.

f. ‘Disulfiram like reaction’ (A typical aversive reaction characterized by flushing, vomiting and arrhythmias) can occur if patients consume alcohol during this perioD.

g. The drug has lower efficacy and results depend upon patient motivation.

h. Naloxone undergoes quick redistribution and therefore is a short acting drug. It therefore has to be given repeatedly.

i. It is the drug of choice for opioid overdose

Analgesics Flashcard List

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