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Medicine

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Liver & GIT

Question
18 out of 27
 

All of the following are true regarding a patient with acid peptic disease except (PNQ)



A Misoprostol is the drug of choice in patients on NSAIDS

B DU is preventable by the use of single night time H2 blockers

C Omeprazole may help ulcers refractory to H2 blockers

D Misoprostol is DOC in pregnant patients

Ans. D Misoprostol is DOC in pregnant patients.

Treating peptic ulcers

Table 293-4 Regimens Recommended for Eradication of H. Pylori Infection (H-18thPg- 2449)

Drug

A. Triple Therapy

1. Bismuth subsalicylate plus

i. Metronidazole plus ii. Tetracycline

2. Ranitidine bismuth citrate plus

i. Tetracycline plus ii. Clarithromycin or metronidazole

3. Omeprazole (lansoprazole) plus

i. Clarithromycin plus ii. Metronidazole or iii. Amoxicillin

B. Quadruple Therapy

i. Omeprazole (lansoprazole) ii. Bismuth subsalicylate iii. Metronidazole iv. Tetracycline

1. H. pylori eradication therapy

Triple therapy is 80-85% effective at eradication.

i. Drugs to reduce acid: PPls are the most effective, eglansoprazole.

ii. H2RAs egranitidine

2. NSAID-associated ulcers: Stop NSAID if possible (if not, use H2RA, PPI, or misoprostol for prevention).

3. Antibiotic : Any of the two – Ampicillin or Amoxicillin + Erythromycin or Clarithromycin + Metronidazole or Tinidazole + Ciprofloxacin or Ofloxacin.

4. Coating agent: Bismuth colloid or Sucralfate

S/E of sucralfate - PO4, constipation gastric Bezoar formation.

Liver & GIT Flashcard List

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