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Pathology

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The Endocrine System

Question
3 out of 32
 

All of the following are true about Hashimoto’s thyroiditis, except? (AIIMS Nov 2014)



A Follicular destruction

B Increase in lymphocytes

C Oncocytic metaplasia

D Orphan Annie eye nuclei

Ans. D i.e., Orphan Annie eye nuclei {Ref:- Robbins 8th e p. 1112)

Pathological features of Hashimoto's thyroiditis

a. Gross features

i. Diffuse symmetrically enlarged thyroid

ii. Although the gland is symmetrically enlarged, the accentuation of lobulations may make the gland appear lobular on gross examination.

iii. Capsule is intact

iv. Cut surface is pale, yellow firm and lobulated.

b. Microscopic features

i. Atrophy of thyroid follicles (atrophic follicles)

ii. Extensive lymphoplasmacytic infiltrate with abundant small lymphocytes and plasma cells with destruction of follicles

iii. Oncocytic metaplasia (Hurthle cell metaplasia) →The surviving follicular epithelial cells are commonly transformed into large cells with abundant pink cytoplasm and are known as Hurthle cells.

iv. Oncocytic metaplasia (Hurthle cell metaplasia) is also known "oxyphilic change" in epithelial cells and is considered the hallmark of Hashimoto's thyroiditis.

v. Varying degree of fibrosis and foci of squamous metaplasia within atrophic follicles.

vi. Interstitial connective tissue is increased and may be abundant.

The Endocrine System Flashcard List

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