All of the following are CORRECT regarding Methicillin resistant Staphylococci EXCEPT
|A||MRSA indicates resistance to all beta lactamases|
|B||MRSA resistance is Beta lactamase independent|
|C||It is Plasmid dependent|
|D||At 37oC resistance is more expressed|
a. Methicillin: It is highly penicillinase resistant but not acid resistant, hence must be injected. It is also an inducer of penicillinase production.
b. MRSA have emerged in many areas. These are insensitive to all penicillinase- resistant penicillins and to other beta-lactams as well as to erythromycin, aminoglycosides, tetracyclines, etc. The MRSA have altered PBPs which do not bind penicillins.
c. The drug of choice for these organisms is vancomycin / linezolid, but ciprofloxacin can also be used.
d. Staph. auresu (MRSA. are not resistant to Gram-negative beta-lactamases.