Autonomic Nervous Systems
All of the following are useful in relieving Post-op urinary spasm EXPECT (LQ)
a. Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence.
b. Tolterodine: This relatively M3 selective muscarinic antagonist has preferential action on urinary bladder; less likely to cause dryness of mouth and other anticholinergic side effects. It is indicated in overactive bladder with urinary frequency and urgency. Since it is metabolized by CYP3A4, dose should be halved in patients receiving CYP3A4 inhibitors (erythromycin, ketoconazole, etc.)
c. Bethanechol is a parasympathomimetic choline ester that selectively stimulates muscarinic receptors without any effect on nicotinic receptors. Bethanechol is used to treat urinary retention resulting from general anesthetic or diabetic neuropathy of the bladder, etC.