All of the following are TRUE about Penicillin G EXCEPT
|A||Can be given orally|
|B||Main mechanism of action is cell wall synthesis inhibition|
|C||Probenecid decreases its secretion|
|D||Effective against Gram-positive bacteria|
a. Antibacterial spectrum: PcG is a narrow spectrum antibiotic; activity is limited primarily to Gram-positive bacteria and few others.
b.Penicillin G is acid labile—destroyed by gastric aciD. So it is not given orally
c. The pharmacokinetics of PnG is dominated by very rapid renal excretion; about 10% by glomerular filtration and the rest by tubular secretion.
d.Tubular secretion of PnG can be blocked by probenecid; higher and longer lasting plasma concentrations are achieveD.
e.Penicillin act by inhibiting cell wall synthesis.
f. They are bactericidal drugs.