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Biochemistry

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Carbohydrates

Question
30 out of 40
 

All of the following is true about HMP pathway except(AIPG 2007)



A Occurs in cytosol

B Produces NADPH

C H+ acceptor is NADP

D End product is pyruvate

Ans. D End product is pyruvate

3G6-P+6NADP→2G-6P+3CO2 +6lyciraldehyde -3P+ 6 NADPH

a. G-6-P Dehydrogenase-Rate limiting enzyme (NADPH Competitive inhibitor)

b. No ATP directly produced or consumed

c. 2NADPH produced per Glu-6-P entering oxidative path of cycle

d. 5 Carbon intermediates Ribose (involved in nucleic acids synthesis)

e. Others-Ribulose (5C), Xylulose (5C), Sedoheptulose­ (7C), Erythrose (4C)

f. Uses of NADPH-Reductive biosynthesis

g. Reduction of H2O2àGlutathione reductase

h. Cytochrome P450 mono oxygenase system

i. Synthesis of NO

j. Phagocytosis of WBC (def. of NADPH oxidase à Chronic granulomatous disease)

k. G6PD Deficiency

i. Erythrocytes are totally dependant on HMP pathway for NADPH, therefore G6PD def. leads to hemolysis

ii. Most common disease producing enzyme abnormality in humans

iii. X-linked

iv. Increased resistance to falciparum malaria (and also to sickle cell trait, thalassemia minor)

v. Duffy negative-vivax resistant

Carbohydrates Flashcard List

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