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Medicine

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Hematology

Question
3 out of 6
 

All of the following statements about Hairy cell leukaemia are true except: (AIPG 2009)



A Splenomegaly is present

B Results from an expansion of neoplastic T lymphocytes

C Cells are positive for Tartrate Resistant Acid phosphatase

D The cells express CD25 consistently

Ans. B

Results from an expansion of neoplastic T lymphocytes

Investigation

1. Severe neutropenia, monocytopenia and the characteristic hairy cell in blood

2. Bone marrow tap are typical dry so bone marrow biopsy is mandatory.

3. These cell usually type as B lymphocytes but characteristically express CD25. (FAQ)

4. A characteristic test is the demonstration that the acid phosphatase staining reaction in the cell is resistant to the action of tartrate. (FAQ)

5. The neutrophil alkaline phosphatase score is very high. (FAQ)