All of the following statements about mycopheno-late mofetil are true except (AI 2010)
|A||It is a prodrug|
|B||Gastrointestinal toxicity is common|
|C||It is used in transplant recipients where other drugs are not effective|
|D||It is highly nephrotoxic|
· Mycophenolate mofetil is a prodrug, its active metabolite is mycophenolic acid.
· It is used as an immunosuppressant drug in solid organ transplant patients for refractory rejection and as an alternative to cyclosporine / tacrolimus in patients who do not tolerate these drugs.
· Major toxicity is gastrointestinal (nausea, vomiting, diarrhea, abdominal pain). It can also cause hypertension and reversible neutropenia.
· Unlike cyclosporine and tacrolimus, it does not cause nephrotoxicity.