All of the following statements about immunosup- -pressants are true EXCEPT (AI-2009)
|A||Sirolimus acts by inhibiting the action of lL-2.|
|B||Tacrolimus inhibits calcineurin pathway|
|C||Mycophenolate acts by inhibiting GMP dehydrogenase|
|D||Cyclosporine is an integeral component of transplant rejection regimen|
a. Mycophenolate mofetil acts by blocking IMP dehydrogenase.
b. Cyclosporine and tacrolimus are calcineurin inhibitors that act by decreasing the transcription of lL-2 gene.
c. Sirolimus acts by inhibiting m-TOR (a tyrosine kinase) that is the target of 1L-2.