Male Genital Tract
All of the following statements about Gleason grading system are true except: (AIIMS Nov 2013)
|A||Score range from 1 to 10|
|B||High score is associated with bad prognosis|
|C||Helps in grading of tumor|
|D|| Helps decide treatment modality|
a. A Gleason score is given to prostate cancer based upon its microscopic appearance. cancers with a higher Gleason score are more aggressive and have a worse prognosis.
b. The pathologist assigns a grade to the most common tumor, and a second grade to the next most common tumor' The two grades are added together to get a Gleason score. For example, if the most common tumor was grade 3, and the next most common tumor was grade 4, the Gleason score would be 3 + 4 = 7.
c. The Gleason grade ranges from 1 to 5, with 5 having the worst prognosis. The Gleason score ranges from 2 to 10, with 10 having the worst Prognosis.
d. It should be noted that for Gleason score 7, a Gleason 4+3 is a more aggressive cancer than a Gleason 3+4' Also' there is not really any difference between the aggressiveness of a Gleason score 9 or 10 tumour.
e. Gleason scores are associated with the following features:
i. Grade 1: The cancerous prostate closely resembles normal prostate tissue. The glands are small, well-formed' and closely Packed
ii. Grade 2: The tissue still has well-formed glands, but they are larger and have-more tissue between them.
iii. Grade 3: The tissue still has recognizable glands, but the cell are darker. At high magnification, some of these cells have left the glands and are beginning to invade the surrounding tissue.
iv. Grade 4: The tissue has few recognizable glands. Many cell are invading the surrounding tissue.
v. Grade 5: The tissue dose not have recognizable glands. There are often just sheets of cells throughout the surrounding tissue.
The Gleason score is used to help evaluate the prognosis of men with Prostate cancer, Together with other parameters, the Gleason score is incorporated into a strategy of Prostate cancer staging which predicts prognosis and helps guide therapy.