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Dermatology

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Introduction of Skin Diseases

Question
10 out of 23
 

All statements are true regarding skin except- (LQ)



A Skin is stratified squamous epithelium

B Melanocyte & merkel cells are immigrant cells

C Keratin filaments are a hallmark of epidermal cells

D Keratinization process cause hydration of cells

E Spines of spinous cells are formed from housekeeping organelle

Ans. D
i.e., Keratinization process cause hydration of cells & "e' i.e., Spines of spinous cells are formed from housekeeping organelle

Following events occur during keratinization

a. Increase in cell size

b. Flattening of cells

c. Appearance of new cellular organelles, e.g. lamellar granules in stratum spinosum, keratohyaline granules and Odland bodies in stratum granulosum.

d. Metabolism changes from generalized to more focused with the synthesis of molecules (structural proteins and lipids) related to keratinization.

e. Progressive dehydration (not hydration).

f. Progressive shortening and finally disappearance of nucleus.

g. Changes in enzymes with degradation of cellular organelles and chromatin fragmentation àapoptosis in stratum corneum.

h. Finally dead cells to break apart and slough away, a process known as desquamation.

About other options

a. Spines of cells in stratum spinosum are due to presence of prominent intracellular desmosomal connections.

b. Housekeeping organelle (RER, golgi complex, lysosome, ribosomes and mitochondria) are found in keratinocytes.

c. There are two types of cells in epidermis:-

i. Local cells (develop from ectoderm along with epidermis) àkeratinocytes.

ii. Immigrant cells (develop elsewhere and migrate to epidermis).

A. Melanocytes }

B. Merkel cells } àdevelop from neural crest and migrate into epidermis.

C. Langerhans cells à derived from mesenchyme and migrate into epidermis.

d. Skin is stratified squamous epithelium.

e. Keratin filaments are the hallmark of epidermal cells (keratinocytes).

Introduction of Skin Diseases Flashcard List

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