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Medicine

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Hematology

Question
11 out of 29
 

All the following are true about multiple myeloma except: (DNB June 2010)



A Osteolytic bone disease

B t(8-14) translocation

C Renal failure

D Bence-Jones proteins in urine

Ans. B

t(8-14) translocation

1. A variety of chromosomal alterations have been found in patients with myeloma; 13q14 deletions, 17p13 deletions, and 11q abnormalities predominate.

2. The most common translocations are t(11;14)(q13;q32) and t(4;14)(p16;q32), errors in switch recombination—the genetic mechanism to change antibody heavy chain isotype—participate in the transformation pathway. (Ref. Hari-18th ed., Pg. 941)

Hematology Flashcard List

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