All the following are true about multiple myeloma except: (DNB June 2010)
|A||Osteolytic bone disease|
|D||Bence-Jones proteins in urine|
1. A variety of chromosomal alterations have been found in patients with myeloma; 13q14 deletions, 17p13 deletions, and 11q abnormalities predominate.
2. The most common translocations are t(11;14)(q13;q32) and t(4;14)(p16;q32), errors in switch recombination—the genetic mechanism to change antibody heavy chain isotype—participate in the transformation pathway. (Ref. Hari-18th ed., Pg. 941)