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Pharmacology

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Autonomic Nervous Systems

Question
29 out of 75
 

All the following can be used to treat erectile dysfunction EXCEPT:



A Phenylephrine
B Papaverine

C Sildenafil
D Apomorphine

Ans. A Phenylephrine

Drugs Used In Erectile Dysfunction:

  1. Sildenafil/ Tildenafil
  2. Androgenic drugs
  3. Alprostadil
  4. Papaverine
  5. Phentolamine
  6. Apomorphine

Papaverine/Phentolamine Induced Penile Erection (PIPE) therapy for impotence In patients unable to achieve erection, injection of papaverine (3-20 mg) with or without phentolamine (0.5-1 mg) in the corpus cavernosum has produces penile tumescence to permit intercourse.

a. This is reversed by aspirating blood from the corpus cavernosum or by injecting phenylephrine locally.

b. Historically, apomorphine has been tried for a variety of uses including psychiatric treatment of homosexuality.

c. Currently, apomorphine is used in the treatment of Parkinson's disease and erectile dysfunction.

d. It was also successfully used in the treatment of heroin addiction.

e. For treatment of erectile dysfunction, it is believed that dopamine receptors in the hypothalamic region of the brain are the main target, as although dopamine receptors in the penis do facilitate erection, they do so far more weakly than those in the brain.

f. It is a potent emetic.

g. The drug reduces prolactin; therefore can correct impotence secondary to increased prolactin levels.

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