Metabolic Bone Diseases
All the following may be sequelae of Paget's disease of bone EXCEPT
|A||Bowing of the tibia|
a. Osteoporosis circum scripta is a characteristic osteolytic lesion in the skull associated with the early phases of Paget's disease. Severe bowing of the long bones, especially the tibia, can occur and can lead to stress fractures.
b. Bony overgrowth and collapse of vertebral bodies can lead to neurologic impairment and paraplegia. Secondary sarcomatous transformation is a major but rare sequela of Paget's disease. "Codfish" vertebrae are associated with osteoporosis, whereas Paget's disease often produces a bone-within-a-bone appearance, often referred to as a "picture frame" vertebra.