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Physiology

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Endocrinology

Question
3 out of 10
 

All use cAMP as second messenger except (AIIMS NOV 2009)



A Corticotropin
B Dopamine

C Glucagon
D Vasopressin

Ans. D Vasopressin
  1. Corticotropin Q& Glucagon Q both act by stimulating adenylyl cyclase which in turn increase cAMP.
  2. Dopamine has 5 receptor. D1& D5 act by increasing cAMP Q (via adenylyl cyclase) & D2,D3& D4 act by decreasing cAMP Q.
  3. Whereas ADH has 2 receptors VR 1(A & B) acts viaIP3/DAG mechanism Qand VR2 which acts by increasing cAMP Q in tubular cells, it is important for water reabsorption in Collecting duct (by aquaporin 2) Q. Other Hormones acting via cAMP are

CRH, FSH, MSH Q, TSH Q, LH Q ,α2 & β adr. receptors Q ,PTH Q ,ADH, AT II (epithelium), Secretin, HCG,

Glucagon somatostatin, Lipotropin, Calcitonin