Allosteric inhibition with ATP affects
1. In glycolysis path: -
2. Phosphofructokinase is both an allosteric and an inducible enz whose activity is considered to play a major role in regulation of rate of glycolysis.
3. Phosphofructo kinase →
a. its Activators — eg.
ii. fructose-2,6 bisphosphate in liver
iii. fructose 1,6— bisphosphate in muscles.
b. Its, Inhibitors —
i. citrate (fatty acid, ketone body)
ii. ATP, cAMP (not AMP, which is activator)
4. PASTEUR effects:
i. Aerobic oxidation (Via citric acid cycle) inhibit the Anaerobic degradation of glucose (ie.
ii. Mech → In presence of O2 (Aerobic), TCA cycle operates more →ATP → which
inhibit phosphofructokinase I, and thus decreasing glycolysis.
5. Carb tree effect - is opposite Pasteur effect which represents decreased respiration of cellular systems caused by high concentration of glucose.