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Pharmacology

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Endocrinology

Question
37 out of 93
 

Amantadine used prophylactically against influenza A2, is thought to act by? (LQ)



A Presenting production of viral capsid protein

B Preventing virion release

C Preventing penetration of the virus into the host cell

D Preventing uncoating of viral DNA

Ans. D Preventing uncoating of viral DNA

a. Amantadine mechanism of action involves inhibition of uncrating of the influenza A viral DNA. The primary target is the membrane M2 protein.

b. The drug does not affect penetration and DNA-dependent RNA polymerase activity Amantadine both reduces the frequency of illness and diminishes the serologic response to influenza infection.

c. The drug has no action, on influenza B. As a weak base, amantadine buffers the pH of endosomes, thus blocking the fusion of the viral envelope with the membrane of the endosome.

etom11Beta

This causes a normal adrenal cortex to synthesize increased amounts of 17- hydroxylated steroids, which can be measured in the urine. However, patients who have disease of the hypothalamico-pituitary axis do not produce ACTH in response to metyrapone.

As a result, we find no increased levels of the steroids in the urine. Before administering metyrapone we need to test responsiveness of the adrenal cortex to respond to administration of ACTH.

Endocrinology Flashcard List

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