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Microbiology

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RNA Viruses

Question
48 out of 94
 

An HIV-positive patient, prior to being treated with AZT, DDI, and saquinavir, has a CD4 Lymphocyte count and an HIV RNA viral load test done. Result are as follows:

CD4: 50 CD4 Lymphocytes per μL

HIV RNA: 100,000 copies per mL

Which of the following statements best describes this patient?



A This patient is no longer in danger of opportunistic infection

B The five-year prognosis is excellent

C The patient’s HIV screening test is most likely negative

D The viral load of 100,000 copies per mL suggests that the patient will respond to triple therapy

Ans. D The viral load of 100,000 copies per mL suggests that the patient will respond to triple therapy

a. The advent of triple therapy, or a therapeutic “cocktail,” has had a marked effect on AIDS patients.

b. The combination of drugs works together as reverse transcriptase inhibitors and a protease inhibitor. Patients improve rapidly, their CD4 lymphocyte counts increase, and their HIV viral loads are drastically reduced, often to less than 50 copies per mL.

c. On the other hand, an untreated HIV-positive patient with a low CD4 and a high viral load

d. Is at increased risk of opportunistic infection and

e. Has a much greater chance of developing AIDS than if the viral load was less than 10,000. The patient is infectious and his HIV antibody screening test will be positive.

f. The high viral load, however, is not a predictor of response to therapy Many patients with high viral loads do very well on triple therapy, although resistance to one or more of the agents may subsequently occur.

g. A low CD4 count does not predict progression to AIDS but does indicate increased chance of opportunistic infection:

RNA Viruses Flashcard List

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