CNS Part- 2
2 out of 42
An SSRI antidepressant (eg. Fluoxetine) will be prescribed for an adult patient. You should advise him or her that two most likely side effects or adverse responses that may eventually occur at therapeutic blood levels are which of the following? (LQ)
|A||Intense dizziness upon standing and palpitations.|
|B||Migraine headache and involuntary skeletal muscle twitching|
|C||Polyuria and insatiable thirst|
|D||Sexual dysfunction and weight gain.|
Ans. D Sexual dysfunction and weight gain
- Sexual dysfunction (probably of CNS origin) and weight gain (sometimes significant) are relatively common problems associated with SSRI therapy. Orthostatic hypotension and reflex tachycardia sometimes occur with older antidepressants (tricyclics, e.g., imipramine), but are rare with SSRIs.
- Migraine is not likely; blockade of serotonin reuptake might actually reduce the risk (note that triptans exert antimigraine actions by acting as serotonin agonists). Lithium is the drug likely to cause polyuria and polydipsia. None of the other side effects or adverse responses listed in the question are likely with an SSRI.
CNS Part- 2