An anti-emetic drug that also decreases acid secretion due to its action on receptors is
· Promethazine is a first generation Hi-antihistaminic drug. It is indicated for treatment of allergic reactions.
· Due of its anticholinegic action and ability to cross blood brain barrier, it can be used as an antiemetic (particularly for prophylaxis of motion sickness) and as an anti-Parkinsonism drug (particularly in drug induced Parkinsonism).
· Acid secretion is reduced mainly by H2-blocking drugs like ranitidine and even first generation anti-histaminics can also reduce acid secretion at high doses (due to lack of selectivity at such high dose).