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Pharmacology

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GIT

Question
40 out of 53
 

An anti-emetic drug that also decreases acid secretion due to its action on receptors is

(AI 2010)



A Promethazine
B Domperidone

C Metoclopramide
D Ondansetron

Ans. A Promethazine (Ref. : Katzung 11 th/1977)

· Promethazine is a first generation Hi-antihistaminic drug. It is indicated for treatment of allergic reactions.

· Due of its anticholinegic action and ability to cross blood brain barrier, it can be used as an antiemetic (particularly for prophylaxis of motion sickness) and as an anti-Parkinsonism drug (particularly in drug induced Parkinsonism).

· Acid secretion is reduced mainly by H2-blocking drugs like ranitidine and even first generation anti-histaminics can also reduce acid secretion at high doses (due to lack of selectivity at such high dose).

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