An asthma patient has been receiving oral anhydrous theophylline (theophylline base) for some time, and now we plan to switch to the sodium glycinate salt – one of several theophylline salts available – for continued oral therapy. How does the sodium glycinate salt, or any theophylline salt for that matter, differ from anhydrous theophylline?
Eliminated renally; no dependence on metabolism
|A||Have much greater margins of safety|
|B||Less potent on a mg-for-mg basis|
|C||Radically different side effects profiles|
|D||Is less efficacious|
The various theophylline salts (sodium glycinate, monohydrate, others, made mainly to increase solubility compared with anhydrous theophylline) are less potent on a mg-for-mg basis than the “gold standard,” anhydrous theophylline (theophylline base). Once absorbed, the salts dissociate and form theophylline in the blood.