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Pharmacology

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Respiratory Systems

Question
4 out of 47
 

An asthma patient has been receiving oral anhydrous theophylline (theophylline base) for some time, and now we plan to switch to the sodium glycinate salt – one of several theophylline salts available – for continued oral therapy. How does the sodium glycinate salt, or any theophylline salt for that matter, differ from anhydrous theophylline?

Eliminated renally; no dependence on metabolism



A Have much greater margins of safety

B Less potent on a mg-for-mg basis

C Radically different side effects profiles

D Is less efficacious

Ans. C Radically different side effects profiles)

The various theophylline salts (sodium glycinate, monohydrate, others, made mainly to increase solubility compared with anhydrous theophylline) are less potent on a mg-for-mg basis than the “gold standard,” anhydrous theophylline (theophylline base). Once absorbed, the salts dissociate and form theophylline in the blood.

Respiratory Systems Flashcard List

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