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Pharmacology

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Question
8 out of 45
 

An important biochemical consequence of vitamin B12 deficiency is accumulation of(LQ)



A Dihydrofolate
B dTMP

C Folic acid
D N5-ethyltetrahydrofolate

E Tetrahydrofolate

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After undergoing surgery for breast cancer, a 53 year-old woman is scheduled to receive 4 cycles of cancer chemotherapy. The cycles are to be administered every 3-5 weeks. Her first cycle was complicated by severe chemotherapy-induced thrombocytopenia.

Ans. D N5-methyltetrahydrofolate

The conversion of N5-methyltetrahydrofolate to methyltetrahydrofolate requires adequate supplies of cobalamin (vitamin B12)' In vitamin BIZ deficiency, N5-methyltetrahydrofolate accumulates, whereas supplies of dihydrofolate, tetrahydrofolate, and dTMP are depleted.

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