Loading....
Coupon Accepted Successfully!

Pathology

Open Flashcards

Female Genital Tract

Question
11 out of 15
 

An ovarian neoplasm in a 14-year old girl is most likely to be: (AIIMS May 2012)



A Germ cell tumor

B Epithelial tumor

C Sertoli-Leydig cell tumor

D Granulosa cell tumor

Ans. A Germ cell tumor

Epithelial tumors of ovary usually occur in old age

Germ cell tumors of ovary generally occur in younger women. About 75% of these occur in women <30 years old

Stromal tumors (like Sertoli Leydig tumors and granulosa cell tumors) occur in all ages.

Granulosa- theca cell tumors are mostly seen in post- menopausal loomen.

Sertoli-Leydig cell tumors occur in women of all ages, although the peak incidence is in second and third decade

Thus, we are left with two options: Germ cell tumors and Sertoli Leydig cell tumors. But, if we see the frequency of tumors; germ cell tumors have 15-20% whereas all sex-cord stromal tumors (Sertoli Leydig is one of them) together constitute only 5-10% of ovarian neoplasms

Thus, a 14-year-old girl is most likely to have germ cell tumor.

Important Points About Ovarian Neoplasms

These may develop from epithelial cells (like serous, mucinous, Brenner tumor etc), germ cells (like granulose cell tumor, Sertoli-Leydig cell tumors etc).

Most common ovarian neoplasms are epithelial tumors

Most common malignant ovarian neoplasms are epithelial tumors.

Two types of autosomal dominant familial cancers have been identified:

Breast/ovarian cancer syndrome: Due to mutations in BRCA1 or BRCA2 genes.

Lynch type ll syndrome: Results due to mutations in mismatch repair genes. This is associated with Non-polyposis colorectal cancer, endometrial and ovarian cancer.

CA-125 is marker of epithelial ovarian cancers

Dysgerminoma is ovarian counterpart of seminoma and is highly sensitive to radiation therapy

Female Genital Tract Flashcard List

15 flashcards
1)
2)
3)
4)
5)
6)
7)
8)
9)
10)
11)
12)
13)
14)
15)