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Pharmacology

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Question
22 out of 45
 

Antagonist of heparin is: (DNB Dec 2009)



A Protamine sulfate
B Phylloquinone

C Ticlopidine
D Clopidogrel

Ans. A Protamine sulphate

Ref.: - KDT, 6th, 600.

  • Protamine sulphate is the antagonist for heparin (chemical antagonism).
  • It is indicated in overdose due to heparin as well as where heparin action must be terminated rapidly – after cardiac or vascular surgery. 1 mg of protamine neutralizes approximately 100 units of heparin sulfate; maximum dose, 50 mg intravenously. Phylloquinone is vitamin K derivative, while ticlopidine and clopidogrel are anti-platelet drugs useful for arterial thrombi prophylaxis.

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