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Chloramphenicol

  1. Broad spectrum            
  2. Bacteristatic        
  3. Lipid soluble        
  4. Protein synthesis inhibitor

MAO

  1. 50-S inhibitor
  2. Blocks peptidyl transferase enzyme.
     
    i. Mutation in this enzyme can give rise to resistance.

p/k

  1. Excellent absorption, tissue penetration
  2. Half life-1 hour; undergoes glucoronidation
     
    i. Defective glucoronidation leads to gray baby syndrome

Uses

  1. DOC
    1. Anaerobic brain abscesses
    2. Anti-H. Influenza
    3. Anti-salmonella
    4. Anti-mycoplasma (substitute of tetracyclins in children)
    5. Anti-ricketsae
    6. No activity against chlymyidia infection

S/E

  1. GI upset                      
  2. Aplastic anemia (dependent/independent)
  3. Thrombocytopenia              
  4. Pancytopenia              
  5. Agranulocytosis 

D/I

  1. Inhibits metabolism of cyclophosphamide leading to its toxicity,





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