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Tetracyclins

  1. Antibiotics with 4 rings are called tetracyclins.
  2. Broad spectrum, bacteristatic, water soluble; weak antibiotics

MAO

  1. Inhibit protein synthesis (30 S). 
  2. Attachment of t-RNA to 30 S is inhibited leading to impairment of protein synthesis. 

MOR

  1. Active efflux; failure of drug concentration.

P/k

  1. Well absorbed
  2. Absorption reduced by:
    1. Antacids
    2. Milk foods
  • Absorption of doxycycline, minocycline unaffected
  • FeSO4 also reduced
  • There should be a gap of 1-2 hours between administration.   
  1. Doxycline, minocycline
    1. Eliminated by bile        
    2. Lipid soluble          
    3. Enter blood brain barrier

Uses

  1. DOC
    1. Mycoplasma                  
    2. Ricketsae infection               
    3. Plague (prophylaxis)
    4. Lyme disease                      
    5. Granuloma inguinale            
    6. Lymphogranuloma venerum    
    7. Blind loop syndrome          
    8. Chlamydia except C. Trachomatis      
    9. Cholera (-prophylaxis-tetra; Rx-Doxy)    
  2. Tigecycline
    1. Long acting tetracycline
    2. Eliminated by bile
    3. Active against MRSA/VRSA
    4. Given IV
  3. Demeclocycline
     
    i. DOC for SIADH
  4. Minocycline

DOC for Inflammaed acne


S/E

  1. MC-GI upset
  2. Interfere with bones & teeth
    1. 3-6 years MC affected
    2. Decidous teeth affected
  3. Psedutumor cerebri
  4. Fanconi syndrome
     
    i. Outdated tetracyclins
  5. Prolonged use
     
    i. Increase BUN
  • Muscles become weak
  • Nm blockers potentiated
  1. Minocycline
    1. Vertigo
    2. Hyperpigmentation (remember CAM: chlorpromazine, clofazamine amiodarone and minocycline) 
  2. Doxycline
    1. Fatty liver
    2. Ototoxicty
  3. Doxycycline
     
    i. Phototoxicity
  4. Demeclocycline
    1. Photosensitivity
    2. Nephrogenic diabetes insipidous

 





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