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Reproductive Physiology, Endocrinology, and Infertility

Question
56 out of 56
 

Antihormone used in infertility is: (DNB, Nov. 2008)



A Tamoxifen
B Clomifene

C Danazol
D Finasterid


Ans. A

Tamoxifen

1. Clomifene is a non-steroidal compound related to diethylstilbestrol indicated in:

a. Anovulatory infertility

b. Polycystic ovarian disease associated with infertility

c. In invitro fertilization: GIFT and ART

d. 25 mg orally for 25 days each month for 3 to 6 month to stimulate spermatogenesis.

2. Clomifene citrate stimulates hypothalamic gonadotropin secretion by blocking the negative feedback of estrogen by ovaries. Gonadotropin stimulates pituitary FSH and LH secretion which induces ovulation.

3. Danazol is an isoxazole derivative of 17-α­-ethinyl testosterone used for:

a. Endometriosis

b. Cyclical mastalgia

c. Gynecomastia

d. Fibrocystic disease of breast

e. Improves libido

f. Shrinks fibroid

4. Tamoxifen is a nonsteroidal antiestrogen drug used in palliative treatment of advanced breast cancer in postmenopausal women.

5. Finasteride is a competitive inhibitor of enzyme Sa reductase.

Reproductive Physiology, Endocrinology, and Infertility Flashcard List

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