Loading....
Coupon Accepted Successfully!

 

Antiameobic Drugs

  1. Metronidazole
    1. MC used antiamoebic drug
    2. Damages DNA
    3. Prodrug
    4. Depends upon a nitrogen dependent uptake mechanism to be activated
    5. This mechanism is only present in anaerobic bacteria
    6. Hence only active in anerobic bacteria
    7. Well absorbed
    8. Excellent tissue penetration including, eye, prostate, CSF

Uses

 

a. DOC

  1. Amoebiasis                    
  2. Giardiasis                      
  3. Trichomonas       
  4. Bacterial vaginosis              
  5. Eradication of H.Pylori          
  6. Anaerobic infections            
  7. Vincent’s infection              
  8. Ludwing’s angina

Side effect

  1. Nausea                  
  2. Vomiting                      
  3. Disulfiram like reaction
  4. Metallic taste                      
  5. Neuropathy on long term use

C/I

  1. Hepatic & renal failure          
  2. Hematological disorder
  3. Epilepsy                      
  4. Psychiatric disorders 

2. Tinidazole

  • More potent, longer acting than metronidazole  
  1. Emetine & DHE
    1. Plant derived alkaloid            
    2. Short acting                  
    3. Inhibit protein synthesis
    4. Given IM                    
    5. Used in resistant cases          
    6. Cardiotoxic-arrythmias can occur 
  2. Nitroimidazoles
    1. Satranidazole
    2. Ornidazole
    3. Secnidazole
      1. Used in single doses
      2. Satranidazole-safest 
  3. Diloxanide furate
    1. Pro-drug
    2. Luminal drug
    3. Used for intestinal amoebiasis of asymptomatic type
    4. Puromomycin is used more commonly
    5. Side effect
       
      Dyspepsia 
  4. Idoquinol       
    1. Weak antiamoebic drug
    2. Causes subacute optic myeloneuropathy (SMON)
    3. Banned drug 
  5. Mepacrine
    1. Antimalarial
    2. Antigiardia
    3. Antiameoba
      1. Concentrates in RBCs
      2. Imparts discoloration to skin (Brown pigmentation)
      3. Banned drug





Test Your Skills Now!
Take a Quiz now
Reviewer Name