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Pharmacology

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Antibiotics Part-1

Question
76 out of 86
 

Aplasia of the bone marrow not seen with



A Methicillin
B Chloramphenicol

C Methyl hydantoin
D Chlorpromazine

Ans. A Methicillin

Agents that regularly produce marrow depression as major toxicity in commonly employed does or normal exposures: Cytotoxic drugs used in cancer chemotherapy: alkylating agents antimetabolites, antimitotics, some antibiotics.

Agents that frequently but not inevitably produce marrow aplasia Benzene.

Agents associated with aplastic anemia but with a relatively low probability:

Chloramphenicol.

Insecticides

Antiprotozoals: quinacrine and chloroquine, mepacrine

Nonsteroidal anti-inflammatory drugs (including phenylbutazone, indomethacin, ibuprofen, sulindac, aspirin)

Anticonvulsants (hydantoins, carbamazepine, phenacemide, felbamate,

Heavy metals (gold, arsenic, bismuth, mercury)

Sulfonamides : some antibiotics, antithyriod drugs (methimazole, methylthiouracil, propylthiouracil) antidiabetes drugs (tolbutaminde, cholrpropamide) carbonic anhydrase inhibitors (acetazolamide and methazolamide)

Antihistamines (cimetidine, chlorpheniramine)

D-Penicillamine

Estrogens (in pregnancy and in high does in animals) whose association with aplastic anema is more tenuous:

Other antibiotics (streptomycin, tetracycline, methicillin, mebebendazole (trimethoprim/sulfamethoxazole, flucytosine)

Sedatives and tranqulizers (chlorpromazine, prochlorperazine, piperacetazine, chlordiazpoxide, meprobamate, methyprylon)

Allopurinol

Methydopa

Quinidine

Lithium

Guanidine

Potassium perchlorate

Thiocyanate

Carbimazole

As per Harrisons, answer is none.

Table does not mention methicillin, all other three options were given. This question probably is framed based on this table. Hence, the answer is likely to be methicillin.

Antibiotics Part-1 Flashcard List

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