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Pharmacology

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CNS Part-1

Question
39 out of 58
 

Appetite suppressors are A/E (AIIMS Nov 2009)



A Melanocyte stimulating hormone

B Melanocyte corticotropic releasing hormone

C Neuropeptide Y

D None of these

Ans. C Neuropeptide Y

a. Alpha-Melanocyte-stimulating hormone (alpha-MSH) and corticotropin-releasing hormone (CRH) both suppress food intake, and the alpha-MSH- or CRH-signaling pathway has possible potency to mediate anorexic actions induced by most other neuropeptides in goldfish.

b. Neuropeptide Y (NPY) is the most abundant neuropeptide in the brain. It is a member of a family of proteins that include pancreatic polypeptide, peptide YY and seminal plasmin. In addition to its function in feeding behavior, several other physiologic roles have been assigned to NPY, including involvement in circadian rhythms, sexual function, anxiety responses and vascular resistance. NPY is known to be an extremely potent stimulator of feeding behavior.

c. Feeding behavior in rodents is blocked by injection of antibodies or antisense RNAs against NPY. More importantly, leptin appears to act, at least in part, by inhibiting NPY synthesis and release in the hypothalamus.

d. Additionally, mutations that interfere with signaling via the hypothalamic melanocortin-4 receptor lead to obesity that is at least partially explained by perturbations of NPY expression (BG Katzung’ 10th Edition, pp-386-88).

GAT - (which removes synaptically released GABA into neurons and glial cells.)

CNS Part-1 Flashcard List

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