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Medicine

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Hematology

Question
5 out of 7
 

Arsenic is used in treatment of: (AIIMS May 09)



A Acute promyelocytic leukemia

B A.L.L

C CML

D Transient myeloproliferative disorder

Ans. A

Acute promyelocytic leukemia

Management of AML {Ref. Hari- 18th, Fig 109..2, Page 911}

1. All FAB subtypes except M3 are usually given induction chemotherapy with cytarabine (ara-C) and an anthracycline (most often daunorubicin).

2. This induction chemotherapy regimen is known as "7+3" , because the cytarabine is given as a continuous IV infusion for seven consecutive days while the anthracycline is given for three consecutive days as an IV push.

3. Allogeneic BMT improves long – term remission to 50%

4. Treatment of AML M3

a. All trans retinoic acid (ATRA) is an oral drug specifically used in the treatment of AML M3. It cause retinoic acid syndrome characterised by fever, dyspnea, pulmonary infiltration, pleural and pericardial effusion.

b. Arsenic trioxide – for refractory patients with retinoic acid.

Extra Edge: Treatment of the leukemia can result in pulmonary hemorrhage from lysis of blasts in the lung, called leukemic cell lysis pneumopathy. (Ref. Hari-18th ed., Pg.- 2272)

Hematology Flashcard List

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