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Reproductive Physiology, Endocrinology, and Infertility

Question
23 out of 56
 

At the time of annual examination, a patient expresses concern over exposure to sexually transmitted diseases. During your pelvic examination, a singular, indurated, nontender ulcer is noted on the vulva. VDRL and FTA tests are positive. Without treatment, the next stage of this disease is clinically characterized by:



A Optic nerve atrophy and generalized paresis

B Tabes dorsalis

C Gummas

D Macular rash over the hands and feet

Ans. D

Macular rash over the hands and feet

1. Syphilis is a chronic disease produced by the spirochete Treponema pallidum.

2. Because of the spirochete’s extreme thinness, it is difficult to detect by light microscopy; therefore, spirochetes are diagnosed by use of a specially adapted technique known as dark-field microscopy.

3. Clinically, syphilis is divided into primary, secondary, and tertiary (or late) stages.

4. In primary syphilis a hard chancre develops.

5. This is a painless ulcer with an indurated base that is usually found on the vulva, vagina, or cervix.

6. Secondary syphilis is the result of hematogenous dissemination of the spirochetes and thus is a systemic dis ease.

7. There are a number of systemic symptoms depending on the major organs involved.

8. The classic rash of secondary syphilis is red macules and papules over the palms of the hands and the soles of the feet.

9. The manifestations of late syphilis include optic atrophy, tabes dorsalis, generalized paresis, aortic aneurysm, and gummas of the skin and bones.

Reproductive Physiology, Endocrinology, and Infertility Flashcard List

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