Atropine/glycopyrrolate is given along with neostigmine to:
|A||To increase the potency|
|B||To prevent muscarinic side effects|
|C||To decrease the onset of neostigmine|
|D||To increase the duration of neostigmine|
To prevent muscarinic side effects
a. Neostigmine by inhibiting acetylcholinesterase prevents the degradation of acetylcholine thus increase the concentration of acetylcholine to have competitive antagonism with non-depolarizers.
b. The increased acetylcholine also acts on muscarinic receptors producing muscarinic side effects especially bradycardia. To prevent these side effects anticholinergics like atropine or glycopyrrolate is given along with neostigmine.