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Cholinergic Actions

  1. Brain
    1. Coordinate memory          
    2. Increase muscle tone          
    3. ​Regulate vital functions  
  2. Eye
    1. Meiosis                    
    2. Cyclospasm                
    3. Increase flow of aqueous humor           
    4. Decrease IOP          
    5. Lacrimation
  3. Glands
    1. Salivation        
    2. (Most sensitive)       
    3. Least sensitive- Gastric acid    
    4. Insensitive-Bile/breast milk  
  4. Bronchi
    1. Hypersecretion                    
    2. Bronchospasm
  5. Heart
    1. Decrease in HR                                
    2. AV block                    
    3. Decrease in ERP-atrial fibers—atrial flutter
    4. Bundle of HIS/Purkinje fibers/ventricles-unaffected
  6. Blood vessels
    1. Vasodilator                                
    2. ​Nitric oxide mediated (EDRF)
  7. Stomach & intestines
    1. Contraction of LES                                               
    2. Increase in volume of gastric juice
    3. Increase in tone, amplitude,frequency of contraction            
    4. Prokinetic                          
    5. Dirrohea                                                                      
    6. Abdominal muscle spasm
  8. Hepatobiliary tract
    1. Spasm of spincter of oddi                                
    2. ​Biliary colic may occur
  9. Urinary bladder
    Contraction of, urinary bladder, detrusor and relaxation of triagone leading to urination

  10. Skeletal muscles
    Initial stimulation followed by depolarization block

  11. Sweat glands
    1. Sweating                            
    2. ​Sympathetic cholinergic fibers

 





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