Auxiliary orthotopic liver transplant is indicated in?
|A||Drug induced Fulminant hepatic failure|
|B||Metabolic liver disease|
|C||To tide time for later liver transplant while waiting for HLA matching|
|D||Cryptogenic liver cirrhosis|
Auxiliary liver transplantation
a. Transplantation of an auxiliary liver into a heterotopic position while leaving the diseased organ in situ has been attempted as an alternative for such high-risk individuals, usually in patient of drug induced hepatic toxicity.
b. Transplantation of an auxiliary liver into a heterotopic position while leaving the diseased organ in situ could be a suitable alternative for patients with hepatic enzyme deficiencies such as ornithine transcarbamylase deficiency or Crigler–Najjar type I disease.
c. A partial liver segment with normal enzyme activity corrects the metabolic defect and, in the case of allograft failure, the native liver with the ability to recover function is still present.
d. With an auxiliary liver transplant, the patient's own liver remains within the body, while another whole or partial liver is transplanted just beneath or adjacent to the recipient's. This is an advantage to patients with genetic errors of metabolism, such as Crigler-Najjar syndrome, because the function of their own liver is perfectly normal except for one genetic defect. Auxiliary liver transplants are also an advantage because the patient is not entirely dependent upon the transplanted liver, should it be rejected.
e. Orthotopic liver transplantation refers to a procedure in which a failed liver is removed from the patient's body and a healthy donor liver is transplanted into the same location.
f. Both metabolic bone disease & drug induced hepatic failure are right but most appropriate ans is A.