## Physiology

### Endocrinology

Question
2 out of 8

BMR is low in (AIPG 2010)

 A Hyperthyroid B Obesity C Feeding D Exercise

Ans. B Obesity

a. In Hyperthyroid, Feeding (SDA) & exercise BMR increases (see table in previous Q.)

b. In case of obesity the BMR can be very different. Low BMR (Hypothyroidism) can lead to weight gain.

c. There is little evidence that obese subjects are characterized by an inherently low metabolic rate. Indeed, it has been repeatedly demonstrated that under standardized conditions the obese have higher absolute energy requirements than do the lean, due to the greater mass of metabolically active tissue.

d. As weight is gained both fat and fat-free mass are gained. However, this does not occur at a linear rate as body size increases. As the body gets fatter, a greater ratio of fat to lean tissue is deposited (Forbes, 1982, 1987). Thus adipose tissue expands faster than lean tissue.

e. The metabolic rate of adipose tissue is very low compared with that of lean tissue (Miller & Blythe, 1953). By far the main determinant of resting metabolic rate is fat-free mass (Miller & Blythe, 1953; Webb, 1981).