Basement membrane damage is caused by which type of enzymes(AIPG 2007)
Invasion of ECM is an active process which involves
a. Detachment of tumor cell from each other
b. Attachment of tumor cells to matrix components
c. Degradation of ECM
d. Migration of tumor cells
"3rd step in invasion is local degradation of basement membrane. Several matrix degrading enzymes termed metalloproteinase, including gelatinases, collagenases and stromelysin are involved.