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Physiology

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Endocrinology

Question
34 out of 50
 

Before the onset of puberty, the GnRH neurons are under the inhibitory control of: (LQ)



A Glycine

B Glutamate

C Gamma amino butyric acid (GABA)

D Beta-endorphin

Ans. D Beta-endorphiControl of the onset of puberty
  1. The factors that normally activate or restrain the hypothalamic neurons responsible for GnRH secretion are unknown.
  2. It is clear that GnRH is the major, if not the only, hormone responsible for the onset and progression of puberty.
  3. During the period from birth to puberty, a neural mechanism is operating to prevent the normal pulse release of GnRH. The nature of the mechanism inhibiting the GnRH pulse generator is unknown.
  4. Conversely, opioid peptides such as the enkephalins and -endorphin reduce the frequency of. GnRH pulses
  5. The release of hypothalamic GnRH is also inhibited by melatonin (Samson wright)

Norepinephrine and possibly epinephrine in the hypothalamus increas

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