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Medicine

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Hematology

Question
2 out of 29
 

Bence Jones protein mostly derived from which chains (AIIMS May 2008)



A ALFA
B Gamma

C MEU
D Delta

Ans. B

Gamma

Extra Edge: Bence Jones Protein

1. A Bence Jones protein is a monoclonal globulin protein found in the blood or urine.

2. Causes: a. Multiple myeloma b. Waldenström's macroglobulinemia

3. The proteins are immunoglobulin light chains (paraproteins) and are produced by neoplastic plasma cells. They can be kappa (most of the time) or lambda.

4. The light chains can be immunoglobulin fragments or single homogeneous immunoglobulins.

5. The light chains can be detected by heating or electrophoresis of concentrated urine. Light chains precipitate when heated to 50 - 60 degrees C and redisolve at 90 -100 degrees C.

Hematology Flashcard List

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